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Lastly (or nearly lastly - the next slide contains a bibliography), it is important to give credit where credit is due. Chris and Jeff are the current graduate students in my lab; Chris is working on the type M enzyme from M. jannaschii and Jeff Barnes is testing whether or not Mth1483 is an RNase P protein. Elizabeth Haas, my permanent postdoc and late wife, worked on all aspects of the RNA. Tom did all of the work I described on the 4 archaeal proteins, and Jim (with Elizabeth) sorted out the activity of the archaeal RNA. Andy and Ginger (with Tom) worked out the purification and properties of the holoenzymes from M. jannaschii and M.thermoautotrophicus, and Kirk (with Elizabeth) determined the secondary structure of the RNA. John and Bev worked on various aspects of the RNA, and Danny did mutagenesis and SELEX experiments that I did not have time to talk about in attempt to 'fix' the poor activity of the archaeal RNAs. Early work on the Haloferax enzyme was done by Dave and Dan in Chucks lab at Ohio State, and the early work on Sulfolobus was by Bernadette, Sylvia, and Tom in Norm Pace's lab, which was at Indiana University at the time. We're currently informally collaborating with Donnie in Norm's lab, who's attempting to crystallize the archaeal RNase P proteins and holoenzyme, and Mark Foster (and Ventkat Gopalan's group) at Ohio State, who are solving the structures of the proteins by NMR. There are of course other groups that aren't listed that have also contributed in various ways, especially the Kimura group in Japan and Sid Altman's lab at Yale.

Work in my lab has been supported primarily by the NIH and Ibis Therapeutics, which is a part of Isis Pharmaceuticals.

Thanks!